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61.
Dr. Sophie A.‐L. Thétiot‐Laurent Dr. Jérôme Boissier Dr. Anne Robert Prof. Dr. Bernard Meunier 《Angewandte Chemie (International ed. in English)》2013,52(31):7936-7956
After malaria, schistosomiasis (or bilharzia) is the second most prevalent disease in Africa, and is occurring in over 70 countries in tropical and subtropical regions. It is estimated that 600 million people are at risk of infection, 200 million people are infected, and at least 200 000 deaths per year are associated with the disease. All schistosome species are transmitted through contact with fresh water that is infested with free‐swimming forms of the parasite, which is known as cercariae and produced by snails. When located in the blood vessels of the host, larval and adult schistosomes digest red cells to acquire amino acids for growth and development. Vaccine candidates have been unsuccessful up to now. Against such devastating parasitic disease, the antischistosomal arsenal is currently limited to a single drug, praziquantel, which has been used for more than 35 years. Because the question of the reduction of the activity of praziquantel was raised recently, it is thus urgent to create new and safe antischistosomal drugs that should be combined with praziquantel to develop efficient bitherapies. 相似文献
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The synthesis of novel symmetrical liquid crystalline compounds based on 5-methyl-5-[2-(4-alkyloxyphenyl)-2-hydroxyethyl]-2,2-bipyridines is reported, together with some physical properties. Although the chelating head-groups are connected via a chiral sp3 carbon atom, all the materials are mesomorphic. Intermolecular hydrogen bonding between pyridino and hydroxy fragments in the mesophases is made apparent by FTIR spectroscopy. 相似文献
64.
Laurent Jeannin Janos Sapi Elka Vassileva Pierre Renard Jean-Yves Laronze 《合成通讯》2013,43(9):1711-1719
Three methods have been proposed for the preparation of functionalized 1-oxo-1,2,3,4-tetrahydro-β-carboline-3 carboxylates (3) from which the “acylazide formation-Curtius rearrangement-acid catalyzed ring closure” sequence starling from hemi-ester hemi-acids (8) seemed to be quite general. 相似文献
65.
Dr. Yong Wu Dr. Shanshan Cao Dr. Iskander Douair Prof. Laurent Maron Prof. Xihe Bi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(19):5999-6006
The [2+1] cycloaddition reaction of a metal carbene with an alkene can produce important cyclopropane products for synthetic intermediates, materials, and pharmaceutical applications. However, this reaction is often accompanied by side reactions, such as coupling and self-coupling, so that the yield of the cyclopropanation product of non-silver transition-metal carbenes and hindered alkenes is generally lower than 50 %. To solve this problem, the addition of a low concentration of diazo compound (decomposition of sulfonyl hydrazones) to alkenes catalyzed by either CuOAc or PdCl2 was studied, but side reactions could still not be avoided. Interestingly, however, the yield of cyclopropanation products for such hindered alkenes were as high as 99 % with AgOTf as a catalyst. To explain this unexpected phenomenon, reaction pathways have been computed for four different catalysts by using DFT. By combining the results of these calculations with those obtained experimentally, it can be concluded that the efficiency of the silver catalyst is due to the barrierless concerted cycloaddition step and the kinetic inhibition of side reactions by a high concentration of alkene. 相似文献
66.
Dr. Raphaël Lamare Dr. Romain Ruppert Prof. Corinne Boudon Prof. Laurent Ruhlmann Dr. Jean Weiss 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(65):16071-16081
Polyoxometalates (POMs) can act as unique reservoirs for multiple electron transfers. As POMs display only weak absorption in the visible spectrum, they can be associated with chromophores such as porphyrins and porphyrin antennae. In this Minireview, the research dedicated to the combination of porphyrins and polyoxometalates is put in context and the state of the art identifying the challenges addressed in the optimization of hybrid materials for applications is detailed. 相似文献
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In an earlier work made by the first author with J. Turi (Degenerate Dirichlet Problems Related to the Invariant Measure of Elasto-Plastic Oscillators, AMO, 2008), the solution of a stochastic variational inequality modeling an elasto-perfectly-plastic oscillator has been studied. The existence and uniqueness of an invariant measure have been proven. Nonlocal problems have been introduced in this context. In this work, we present a new characterization of the invariant measure. The key finding is the connection between nonlocal PDEs and local PDEs which can be interpreted with short cycles of the Markov process solution of the stochastic variational inequality. 相似文献
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ZDM – Mathematics Education - 相似文献
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